Study on genetic engineering of Acremonium chrysogenum, the cephalosporin C producer
نویسندگان
چکیده
Acremonium chrysogenum is an important filamentous fungus which produces cephalosporin C in industry. This review summarized the study on genetic engineering of Acremonium chrysogenum, including biosynthesis and regulation for fermentation of cephalosporin C, molecular techniques, molecular breeding and transcriptomics of Acremonium chrysogenum. We believe with all the techniques available and full genomic sequence, the industrial strain of Acremonium chrysogenum can be genetically modified to better serve the pharmaceutical industry.
منابع مشابه
Regulation of cephalosporin biosynthesis.
The filamentous fungus Acremonium chrysogenum is the natural producer of the beta-lactam antibiotic cephalosporin C and is as such used worldwide in major biotechnical applications. Albeit its profound industrial importance, there is still a limited understanding about the molecular mechanisms regulating cephalosporin biosynthesis in this fungus. This review focuses on various regulatory levels...
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The filamentous fungus Acremonium chrysogenum is the industrial producer of the β-lactam antibiotic cephalosporin C. Here, we present the genome sequence of strain ATCC 11550, which contains genes for 8,901 proteins, 127 tRNAs, and 22 rRNAs. Genome annotation led to the prediction of 42 gene clusters for secondary metabolites.
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Cephalosporins belong to the family of beta-lactam antibiotics. Comparing the first-discovered penicillin, cephalosporins have obvious advantages since they are more stable to penicillinase and are more effective to many penicillin-resistant strains. The incidence of adverse effects for cephalosporins is also lower than that for penicillins and other anti-infectious agents. Thus, cephalosporins...
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